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Erastin

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Erastin 是鐵誘導(dǎo)的細胞死亡 (ferroptosis) 誘導(dǎo)劑。Erastin 結(jié)合且抑制電壓依賴性陰離子通道 (VDAC2/VDAC3)。
貨號： HY-15763
參數(shù)品牌：MCE
產(chǎn)品參數(shù)
品牌：MCE
型號： HY-15763
起訂量：1
規(guī)格:：1 mg
價格:：￥500
我知道了
在線客服
產(chǎn)品詳情

Erastin 是鐵誘導(dǎo)的細胞死亡 (ferroptosis) 誘導(dǎo)劑。Erastin 結(jié)合且抑制電壓依賴性陰離子通道 (VDAC2/VDAC3)。

生物活性
 Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3)[1].
體外研究
(In Vitro)
 Erastin triggers oxidative, iron-dependent cell death. Treatment of NRAS-mutant HT-1080 fibrosarcoma cells with the RSL molecule erastin (10 μM) results in a time-dependent increase in cytosolic and lipid ROS beginning at 2 hours[1]. Cell death triggered by erastin is significantly inhibited by antioxidants (e.g., α-tocopherol, butylated hydroxytoluene, and β-carotene) and iron chelators, suggesting that ROS- and iron-dependent signaling is required for erastin-induced ferroptosis. Erastin can directly bind to VDAC2/3 in BJeLR cells. Knockdown of VDAC2 and VDAC3, but not VDAC1, leads to erastin resistance. Erastin has the ability to reduce glutathione level by directly inhibiting cystine/glutamate antiporter system Xc? activity, with activation of the ER stress response[2]. Erastin potently inhibits HT-29 cell survival. Erastin shows a dose-dependent effect, and 30 μM of erastin displays the most dramatic effect[3].
體內(nèi)研究
(In Vivo)
 Intraperitoneal injection of erastin at well-tolerated doses dramatically inhibits HT-29 xenograft growth in severe combined immunodeficient mice[3].
分子量
 547.04
Formula
 C30H31ClN4O4
CAS 號
 571203-78-6
運輸條件
 Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years

*該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。


溶解性數(shù)據(jù)

In Vitro: 

DMSO : 12.5 mg/mL (22.85 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制儲備液
濃度溶劑體積質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.8280 mL 9.1401 mL 18.2802 mL
5 mM 0.3656 mL 1.8280 mL 3.6560 mL
10 mM 0.1828 mL 0.9140 mL 1.8280 mL
*

請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

In Vivo:

——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 1.

    請依序添加每種溶劑： 50% PEG300    50% saline

    Solubility: 5 mg/mL (9.14 mM); Suspended solution; Need ultrasonic

  • 2.

    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (2.29 mM); Clear solution

  • 3.

    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (1.83 mM); Clear solution



參考文獻

[1]. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72.

[2]. Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79.

[3]. Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605.




Erastin
Erastin

Erastin

分享到微信

×
Erastin 是鐵誘導(dǎo)的細胞死亡 (ferroptosis) 誘導(dǎo)劑。Erastin 結(jié)合且抑制電壓依賴性陰離子通道 (VDAC2/VDAC3)。
貨號： HY-15763
品牌：MCE
型號： HY-15763
起訂量：1
規(guī)格:：1 mg
價格:：￥500
15906629305
在線客服
產(chǎn)品詳情

Erastin 是鐵誘導(dǎo)的細胞死亡 (ferroptosis) 誘導(dǎo)劑。Erastin 結(jié)合且抑制電壓依賴性陰離子通道 (VDAC2/VDAC3)。

生物活性
 Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3)[1].
體外研究
(In Vitro)
 Erastin triggers oxidative, iron-dependent cell death. Treatment of NRAS-mutant HT-1080 fibrosarcoma cells with the RSL molecule erastin (10 μM) results in a time-dependent increase in cytosolic and lipid ROS beginning at 2 hours[1]. Cell death triggered by erastin is significantly inhibited by antioxidants (e.g., α-tocopherol, butylated hydroxytoluene, and β-carotene) and iron chelators, suggesting that ROS- and iron-dependent signaling is required for erastin-induced ferroptosis. Erastin can directly bind to VDAC2/3 in BJeLR cells. Knockdown of VDAC2 and VDAC3, but not VDAC1, leads to erastin resistance. Erastin has the ability to reduce glutathione level by directly inhibiting cystine/glutamate antiporter system Xc? activity, with activation of the ER stress response[2]. Erastin potently inhibits HT-29 cell survival. Erastin shows a dose-dependent effect, and 30 μM of erastin displays the most dramatic effect[3].
體內(nèi)研究
(In Vivo)
 Intraperitoneal injection of erastin at well-tolerated doses dramatically inhibits HT-29 xenograft growth in severe combined immunodeficient mice[3].
分子量
 547.04
Formula
 C30H31ClN4O4
CAS 號
 571203-78-6
運輸條件
 Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years

*該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。


溶解性數(shù)據(jù)

In Vitro: 

DMSO : 12.5 mg/mL (22.85 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

配制儲備液
濃度溶劑體積質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.8280 mL 9.1401 mL 18.2802 mL
5 mM 0.3656 mL 1.8280 mL 3.6560 mL
10 mM 0.1828 mL 0.9140 mL 1.8280 mL
*

請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

In Vivo:

——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 1.

    請依序添加每種溶劑： 50% PEG300    50% saline

    Solubility: 5 mg/mL (9.14 mM); Suspended solution; Need ultrasonic

  • 2.

    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (2.29 mM); Clear solution

  • 3.

    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (1.83 mM); Clear solution



參考文獻

[1]. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72.

[2]. Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79.

[3]. Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605.




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