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瀏覽器自帶分享功能也很好用哦~貨號：HY-N0565B
CAS：24390-14-5
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Doxycycline (hyclate)
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) 是一種四環(huán)素抗生素，口服有效的，廣譜的金屬蛋白酶 (MMP) 抑制劑，具有抗菌活性。
生物活性
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]
體外研究(In Vitro)
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) affects growth of glioma cells only under high concentrations[2].
Doxycycline (hyclate) decreases MT-CO1 protein content with concentrations of 1 μg/mL and higher in SVG cells[2].
Doxycycline (1 μg/mL) induce short-hairpin RNA (shRNA) expression in H23 cells[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[2]
| Cell Line: | LNT-229, G55, and U343 glioma cells |
| Concentration: | 0.01, 0.1, 1, or 10 μg/mL |
| Incubation Time: | 4 days |
| Result: | Affected growth of glioma cells only under high concentrations. |
體內(nèi)研究(In Vivo)
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) (oral; 200 or 800 mg/kg/day; for 3 months) reduces active MMP-9 in untreated HT mice in a dose-dependent manner[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 6-month-old female Heterozygous Col3a1-deficient (HT) mice[1] |
| Dosage: | 200 or 800 mg/kg |
| Administration: | Oral; per day; for 3 months |
| Result: | Reduced active MMP-9 in a dose-dependent manner. |
分子量：512.94
Formula：C22H24N2O8.1/2C2H6O.ClH.1/2H2O
CAS 號：24390-14-5
中文名稱：多西環(huán)素鹽酸鹽半乙醇半水合物；強力霉素鹽酸鹽半乙醇半水合物
運輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式：
4°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性數(shù)據(jù)
DMSO : 240 mg/mL (467.89 mM; Need ultrasonic)
H2O : 125 mg/mL (243.69 mM; Need ultrasonic)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9495 mL | 9.7477 mL | 19.4955 mL |
| 5 mM | 0.3899 mL | 1.9495 mL | 3.8991 mL |
| 10 mM | 0.1950 mL | 0.9748 mL | 1.9495 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。
以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶
- 1.
請依序添加每種溶劑： PBS
Solubility: 20 mg/mL (38.99 mM); Clear solution; Need ultrasonic
- 3.
參考文獻(xiàn)：
Doxycycline (hyclate)
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) 是一種四環(huán)素抗生素，口服有效的，廣譜的金屬蛋白酶 (MMP) 抑制劑，具有抗菌活性。
生物活性
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]
體外研究(In Vitro)
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) affects growth of glioma cells only under high concentrations[2].
Doxycycline (hyclate) decreases MT-CO1 protein content with concentrations of 1 μg/mL and higher in SVG cells[2].
Doxycycline (1 μg/mL) induce short-hairpin RNA (shRNA) expression in H23 cells[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[2]
| Cell Line: | LNT-229, G55, and U343 glioma cells |
| Concentration: | 0.01, 0.1, 1, or 10 μg/mL |
| Incubation Time: | 4 days |
| Result: | Affected growth of glioma cells only under high concentrations. |
體內(nèi)研究(In Vivo)
Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) (oral; 200 or 800 mg/kg/day; for 3 months) reduces active MMP-9 in untreated HT mice in a dose-dependent manner[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 6-month-old female Heterozygous Col3a1-deficient (HT) mice[1] |
| Dosage: | 200 or 800 mg/kg |
| Administration: | Oral; per day; for 3 months |
| Result: | Reduced active MMP-9 in a dose-dependent manner. |
分子量：512.94
Formula：C22H24N2O8.1/2C2H6O.ClH.1/2H2O
CAS 號：24390-14-5
中文名稱：多西環(huán)素鹽酸鹽半乙醇半水合物；強力霉素鹽酸鹽半乙醇半水合物
運輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式：
4°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性數(shù)據(jù)
DMSO : 240 mg/mL (467.89 mM; Need ultrasonic)
H2O : 125 mg/mL (243.69 mM; Need ultrasonic)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9495 mL | 9.7477 mL | 19.4955 mL |
| 5 mM | 0.3899 mL | 1.9495 mL | 3.8991 mL |
| 10 mM | 0.1950 mL | 0.9748 mL | 1.9495 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。
以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶
- 1.
請依序添加每種溶劑： PBS
Solubility: 20 mg/mL (38.99 mM); Clear solution; Need ultrasonic
- 3.
參考文獻(xiàn)：
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