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Cyclophosphamide (環(huán)磷酰胺)

Cyclophosphamide 是一種合成的 DNA Alkylator，在化學(xué)上與氮芥類有關(guān)，具有抗腫L及免疫抑制活性。

貨號：HY-17420
CAS：50-18-0

參數(shù)品牌：MCE

產(chǎn)品參數(shù)

品牌：MCE

型號：HY-17420

起訂量：1

規(guī)格:：100mg

價格:：￥720

我知道了

15906629305

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產(chǎn)品詳情

Cyclophosphamide (Synonyms: 環(huán)磷酰胺)

生物活性

Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

IC₅₀ & Target：DNA Alkylator^[1]

體外研究(In Vitro)

Cyclophosphamide (injected i.p.;2mg/mouse in 0.1 mL PBS, in C3H mice bearing SW1 tumors) increases the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six to eight-week old female C3H/HeN mice bearing SW1 tumors^[4]
Dosage:	2 mg/mouse
Administration:	Injected i.p.; 2mg/mouse in 0.1 mL PBS; 4 days
Result:	Increased the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors.

分子量：261.09

Formula：C₇H₁₅Cl₂N₂O₂P

CAS 號：50-18-0

中文名稱：環(huán)磷酰胺

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲存方式

4°C, protect from light

*該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

溶解性數(shù)據(jù)

In Vitro:

DMSO : ≥ 38 mg/mL (145.54 mM)

H₂O : 33.33 mg/mL (127.66 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制儲備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	3.8301 mL	19.1505 mL	38.3010 mL
5 mM	0.7660 mL	3.8301 mL	7.6602 mL
10 mM	0.3830 mL	1.9150 mL	3.8301 mL

請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

In Vivo:

請根據(jù)您的實驗動物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都請先按?nbsp;In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

1.

請依序添加每種溶劑： PBS
Solubility: 50 mg/mL (191.50 mM); Clear solution; Need ultrasonic
2.

請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (9.58 mM); Clear solution
3.

請依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (9.58 mM); Clear solution
4.

請依序添加每種溶劑： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (9.58 mM); Clear solution

參考文獻(xiàn)

[1]. Schwartz PS, et al. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001 Dec;60(6):1268-1279.

[2]. al-Jafari AA, et al. Inhibition of human acetylcholinesterase by cyclophosphamide. Toxicology. 1995 Jan 19;96(1):1-6.

[3]. Harris RN, et al. Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokineticstudy. Cancer Chemother Pharmacol. 1984;12(3):167-72.

[4]. Liu P, et al. Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J Immunother. 2010 Jan;33(1):53-9.

Cyclophosphamide (環(huán)磷酰胺)

Cyclophosphamide 是一種合成的 DNA Alkylator，在化學(xué)上與氮芥類有關(guān)，具有抗腫L及免疫抑制活性。

貨號：HY-17420
CAS：50-18-0

品牌：MCE

型號：HY-17420

起訂量：1

規(guī)格:：100mg

價格:：￥720

15906629305

在線客服

客服一

產(chǎn)品詳情

Cyclophosphamide (Synonyms: 環(huán)磷酰胺)

生物活性

Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.

IC₅₀ & Target：DNA Alkylator^[1]

體外研究(In Vitro)

Cyclophosphamide (injected i.p.;2mg/mouse in 0.1 mL PBS, in C3H mice bearing SW1 tumors) increases the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six to eight-week old female C3H/HeN mice bearing SW1 tumors^[4]
Dosage:	2 mg/mouse
Administration:	Injected i.p.; 2mg/mouse in 0.1 mL PBS; 4 days
Result:	Increased the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors.

分子量：261.09

Formula：C₇H₁₅Cl₂N₂O₂P

CAS 號：50-18-0

中文名稱：環(huán)磷酰胺

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲存方式

4°C, protect from light

*該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

溶解性數(shù)據(jù)

In Vitro:

DMSO : ≥ 38 mg/mL (145.54 mM)

H₂O : 33.33 mg/mL (127.66 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制儲備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	3.8301 mL	19.1505 mL	38.3010 mL
5 mM	0.7660 mL	3.8301 mL	7.6602 mL
10 mM	0.3830 mL	1.9150 mL	3.8301 mL

In Vivo:

請根據(jù)您的實驗動物和給藥方式選擇適當(dāng)?shù)娜芙夥桨?。以下溶解方案都請先按?nbsp;In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

1.

請依序添加每種溶劑： PBS
Solubility: 50 mg/mL (191.50 mM); Clear solution; Need ultrasonic
2.

請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (9.58 mM); Clear solution
3.

請依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (9.58 mM); Clear solution
4.

請依序添加每種溶劑： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (9.58 mM); Clear solution