Protein deglycase DJ-1 against-1

Protein deglycase DJ-1 against-1 是 DJ-1 結(jié)合化合物，依賴地靶向 DJ1。Protein deglycase DJ-1 against-1 可以穿透血腦屏障 (BBB)。Protein deglycase DJ-1 against-1 是神經(jīng)保護(hù)劑，具有用于帕金森病研究的潛力。貨號(hào)：HY-137262 ，CAS：724737-74-0

參數(shù)品牌：MCE

產(chǎn)品參數(shù)

品牌：MCE

型號(hào)：HY-137262

起訂量：1

規(guī)格:：10mg

價(jià)格:：￥500

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產(chǎn)品詳情

Protein deglycase DJ-1 against-1

Protein deglycase DJ-1 against-1 是 DJ-1 結(jié)合化合物，依賴地靶向 DJ1。Protein deglycase DJ-1 against-1 可以穿透血腦屏障 (BBB)。Protein deglycase DJ-1 against-1 是神經(jīng)保護(hù)劑，具有用于帕金森病研究的潛力。

生物活性

Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research^[1].

體內(nèi)研究(In Vivo)

Protein deglycase DJ-1 against-1 (compound-23; 1 mg/kg; IP; pretreatment one hour; daily; for 4 days) significantly restores MPTP induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice

Animal Model:	Wild-type male C57BL/6 mice at 8, 11-12 and 9-12 weeks; DJ-1-knockout male mice at 11-13 weeks^[1]
Dosage:	1 mg/kg
Administration:	IP; pretreatment one hour; daily; for 4 days
Result:	Significantly restored MPTP (30 mg/kg; IP; One hour after injection) induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.

分子量：417.46

Formula：C₂₄H₂₃N₃O₄

CAS 號(hào)：724737-74-0

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式：

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

DMSO : 25 mg/mL (59.89 mM; ultrasonic and adjust pH to 7 with NaOH)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	2.3954 mL	11.9772 mL	23.9544 mL
5 mM	0.4791 mL	2.3954 mL	4.7909 mL
10 mM	0.2395 mL	1.1977 mL	2.3954 mL

*

請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

1.

請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution
2.

請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

參考文獻(xiàn)

[1]. Kazuko Takahashi-Niki, et al. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease.

Protein deglycase DJ-1 against-1

Protein deglycase DJ-1 against-1 是 DJ-1 結(jié)合化合物，依賴地靶向 DJ1。Protein deglycase DJ-1 against-1 可以穿透血腦屏障 (BBB)。Protein deglycase DJ-1 against-1 是神經(jīng)保護(hù)劑，具有用于帕金森病研究的潛力。貨號(hào)：HY-137262 ，CAS：724737-74-0

品牌：MCE

型號(hào)：HY-137262

起訂量：1

規(guī)格:：10mg

價(jià)格:：￥500

15906629305

在線客服

客服一

產(chǎn)品詳情

Protein deglycase DJ-1 against-1

Protein deglycase DJ-1 against-1 是 DJ-1 結(jié)合化合物，依賴地靶向 DJ1。Protein deglycase DJ-1 against-1 可以穿透血腦屏障 (BBB)。Protein deglycase DJ-1 against-1 是神經(jīng)保護(hù)劑，具有用于帕金森病研究的潛力。

生物活性

Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research^[1].

體內(nèi)研究(In Vivo)

Protein deglycase DJ-1 against-1 (compound-23; 1 mg/kg; IP; pretreatment one hour; daily; for 4 days) significantly restores MPTP induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice

Animal Model:	Wild-type male C57BL/6 mice at 8, 11-12 and 9-12 weeks; DJ-1-knockout male mice at 11-13 weeks^[1]
Dosage:	1 mg/kg
Administration:	IP; pretreatment one hour; daily; for 4 days
Result:	Significantly restored MPTP (30 mg/kg; IP; One hour after injection) induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.

分子量：417.46

Formula：C₂₄H₂₃N₃O₄

CAS 號(hào)：724737-74-0

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式：

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

DMSO : 25 mg/mL (59.89 mM; ultrasonic and adjust pH to 7 with NaOH)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	2.3954 mL	11.9772 mL	23.9544 mL
5 mM	0.4791 mL	2.3954 mL	4.7909 mL
10 mM	0.2395 mL	1.1977 mL	2.3954 mL

*

請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。

In Vivo:

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：

——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

1.

請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution
2.

請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

參考文獻(xiàn)

[1]. Kazuko Takahashi-Niki, et al. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease.

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Protein deglycase DJ-1 against-1

Protein deglycase DJ-1 against-1

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Protein deglycase DJ-1 against-1