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Methoprene (Synonyms: 烯蟲酯; ZR-515)
Methoprene 是一種昆蟲幼年生長ji素的模擬物，是一種生長調(diào)節(jié)殺蟲劑，通過作為幼年ji素 (juvenile hormone) 激動劑來顯示其對靶生物的毒性。
生物活性
Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist[1][2].
體外研究(In Vitro)
Methoprene reduces the growth rate of daphnids with evidence of only a single concentration-response line, having a threshold of 12.6 nM. Molt frequency is reduced by methoprene in a concentration-dependent manner, with a response curve corresponding to a 2-segmented line and thresholds at 4.2 and 0.21 nM. An endpoint related to reproductive maturation, the time of first brood deposition, is also affected by methoprene, with a clear concentration-dependent response and a NOEC of 32 nM. Methoprene reduces fecundity according to a 2-segmented line, with thresholds of 24 and < or =0.18 nM. Methoprene elicits significant toxicity to endocrine-related processes in the 5-50 nM concentration range[1].
分子量：310.47
性狀：Liquid
Formula：C19H34O3
CAS 號：40596-69-8
中文名稱：烯蟲酯；烯蟲丙酯；甲氧普烯；甲氧普林
運輸條件
Room temperature in continental US; may vary elsewhere.
儲存方式
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
溶解性數(shù)據(jù)
Ethanol : 100 mg/mL (322.09 mM; Need ultrasonic)
Acetone : ≥ 50 mg/mL (161.05 mM)
DMSO : 25 mg/mL (80.52 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2209 mL | 16.1046 mL | 32.2092 mL |
| 5 mM | 0.6442 mL | 3.2209 mL | 6.4418 mL |
| 10 mM | 0.3221 mL | 1.6105 mL | 3.2209 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。
請根據(jù)您的實驗動物和給藥方式選擇適當?shù)娜芙夥桨?。以下溶解方案都請先按?nbsp;In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶
參考文獻
[1]. Olmstead AW, LeBlanc GL. Low exposure concentration effects of methoprene on endocrine-regulated processes in the crustacean Daphnia magna. Toxicol Sci. 2001;62(2):268-273. [Content Brief]
[2]. Monteiro JP, et al. Toxicity of methoprene as assessed by the use of a model microorganism. Toxicol In Vitro. 2005;19(7):951-956. [Content Brief]
Methoprene (Synonyms: 烯蟲酯; ZR-515)
Methoprene 是一種昆蟲幼年生長ji素的模擬物，是一種生長調(diào)節(jié)殺蟲劑，通過作為幼年ji素 (juvenile hormone) 激動劑來顯示其對靶生物的毒性。
生物活性
Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist[1][2].
體外研究(In Vitro)
Methoprene reduces the growth rate of daphnids with evidence of only a single concentration-response line, having a threshold of 12.6 nM. Molt frequency is reduced by methoprene in a concentration-dependent manner, with a response curve corresponding to a 2-segmented line and thresholds at 4.2 and 0.21 nM. An endpoint related to reproductive maturation, the time of first brood deposition, is also affected by methoprene, with a clear concentration-dependent response and a NOEC of 32 nM. Methoprene reduces fecundity according to a 2-segmented line, with thresholds of 24 and < or =0.18 nM. Methoprene elicits significant toxicity to endocrine-related processes in the 5-50 nM concentration range[1].
分子量：310.47
性狀：Liquid
Formula：C19H34O3
CAS 號：40596-69-8
中文名稱：烯蟲酯；烯蟲丙酯；甲氧普烯；甲氧普林
運輸條件
Room temperature in continental US; may vary elsewhere.
儲存方式
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
溶解性數(shù)據(jù)
Ethanol : 100 mg/mL (322.09 mM; Need ultrasonic)
Acetone : ≥ 50 mg/mL (161.05 mM)
DMSO : 25 mg/mL (80.52 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2209 mL | 16.1046 mL | 32.2092 mL |
| 5 mM | 0.6442 mL | 3.2209 mL | 6.4418 mL |
| 10 mM | 0.3221 mL | 1.6105 mL | 3.2209 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。
請根據(jù)您的實驗動物和給藥方式選擇適當?shù)娜芙夥桨?。以下溶解方案都請先按?nbsp;In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶
參考文獻
[1]. Olmstead AW, LeBlanc GL. Low exposure concentration effects of methoprene on endocrine-regulated processes in the crustacean Daphnia magna. Toxicol Sci. 2001;62(2):268-273. [Content Brief]
[2]. Monteiro JP, et al. Toxicity of methoprene as assessed by the use of a model microorganism. Toxicol In Vitro. 2005;19(7):951-956. [Content Brief]
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