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Tanshinone I

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Tanshinone I 是一種IIA型人重組 sPLA2 和兔重組 cPLA2 抑制劑，IC50 分別為 11 μM 和 82 μM。
參數(shù)品牌：MCE
產(chǎn)品參數(shù)
品牌：MCE
型號：HY-N0134
起訂量：1
規(guī)格:：5mg
價格:：￥400
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產(chǎn)品詳情

Tanshinone I  (Synonyms: Tanshinone A)

Tanshinone I 是一種IIA型人重組 sPLA2 和兔重組 cPLA2 抑制劑，IC50 分別為 11 μM 和 82 μM。

生物活性

Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).


IC50 & Target

IC50: 11 μM (sPLA2), 82 μM (cPLA2)[1].


體外研究(In Vitro)

Tanshinone I inhibits PGE2 formation from LPS-induced RAW macrophages (IC50=38 μM). When Tanshinone I is added simultaneously with LPS, this compound clearly inhibits PGE2 production (IC50=38 μM) at 10-100 μM. Tanshinone I also reduces PGE2 production (IC50=46 μM) when added after COX-2 is fully induced. The fact that Tanshinone I inhibits PGE2 production by pre-induced COX-2 strongly suggests that this compound may directly inhibit COX-2 activity and/or affect PLA2 activity. When Tanshinone I is incubated with two different forms of phospholipase A2 (PLA2), it clearly inhibits sPLA2 (IC50=11 μM) in a concentration-dependent manner. Although being less potent, Tanshinone I also inhibits cPLA2 (IC50=82 μM)[1].


體內(nèi)研究(In Vivo)

Tanshinone I shows antiinflammatory activity in rat carrageenan-induced paw oedema and adjuvant-induced arthritis. In order to establish the anti-inflammatory activity of Tanshinone I, the classical animal models of acute and chronic inflammation [rat carrageenan (CGN)-induced paw oedema and rat adjuvant-induced arthritis (AIA)] are employed. When Tanshinone I is orally administered, it shows significant anti-inflammatory activity against CGN-induced paw oedema (47% inhibition at 160 mg/kg), while the IC50 of indomethacin is 7.1 mg/kg. In AIA, Tanshinone I gives 27% inhibition of secondary inflammation at 18 day with an oral dose of 50 mg/kg/day, whereas prednisolone (5 mg/kg/day) shows potent inhibition (65%)[1].


分子量：276.29


性狀：Solid


Formula：C18H12O3


CAS 號：568-73-0


中文名稱：丹參酮 I


運輸條件：Room temperature in continental US; may vary elsewhere.


儲存方式


Powder-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month


溶解性數(shù)據(jù)


In Vitro: 

DMSO : 2 mg/mL (7.24 mM; Need ultrasonic)

配制儲備液
濃度溶劑體積質(zhì)量1 mg5 mg10 mg
1 mM3.6194 mL18.0969 mL36.1939 mL
5 mM0.7239 mL3.6194 mL7.2388 mL
10 mM---------
*

請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。



參考文獻

[1]. Kim SY, et al. Effects of Tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytother Res. 2002 Nov;16(7):616-20.  [Content Brief]



Tanshinone I
Tanshinone I

Tanshinone I

分享到微信

×
Tanshinone I 是一種IIA型人重組 sPLA2 和兔重組 cPLA2 抑制劑，IC50 分別為 11 μM 和 82 μM。
品牌：MCE
型號：HY-N0134
起訂量：1
規(guī)格:：5mg
價格:：￥400
15906629305
在線客服
產(chǎn)品詳情

Tanshinone I  (Synonyms: Tanshinone A)

Tanshinone I 是一種IIA型人重組 sPLA2 和兔重組 cPLA2 抑制劑，IC50 分別為 11 μM 和 82 μM。

生物活性

Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).


IC50 & Target

IC50: 11 μM (sPLA2), 82 μM (cPLA2)[1].


體外研究(In Vitro)

Tanshinone I inhibits PGE2 formation from LPS-induced RAW macrophages (IC50=38 μM). When Tanshinone I is added simultaneously with LPS, this compound clearly inhibits PGE2 production (IC50=38 μM) at 10-100 μM. Tanshinone I also reduces PGE2 production (IC50=46 μM) when added after COX-2 is fully induced. The fact that Tanshinone I inhibits PGE2 production by pre-induced COX-2 strongly suggests that this compound may directly inhibit COX-2 activity and/or affect PLA2 activity. When Tanshinone I is incubated with two different forms of phospholipase A2 (PLA2), it clearly inhibits sPLA2 (IC50=11 μM) in a concentration-dependent manner. Although being less potent, Tanshinone I also inhibits cPLA2 (IC50=82 μM)[1].


體內(nèi)研究(In Vivo)

Tanshinone I shows antiinflammatory activity in rat carrageenan-induced paw oedema and adjuvant-induced arthritis. In order to establish the anti-inflammatory activity of Tanshinone I, the classical animal models of acute and chronic inflammation [rat carrageenan (CGN)-induced paw oedema and rat adjuvant-induced arthritis (AIA)] are employed. When Tanshinone I is orally administered, it shows significant anti-inflammatory activity against CGN-induced paw oedema (47% inhibition at 160 mg/kg), while the IC50 of indomethacin is 7.1 mg/kg. In AIA, Tanshinone I gives 27% inhibition of secondary inflammation at 18 day with an oral dose of 50 mg/kg/day, whereas prednisolone (5 mg/kg/day) shows potent inhibition (65%)[1].


分子量：276.29


性狀：Solid


Formula：C18H12O3


CAS 號：568-73-0


中文名稱：丹參酮 I


運輸條件：Room temperature in continental US; may vary elsewhere.


儲存方式


Powder-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month


溶解性數(shù)據(jù)


In Vitro: 

DMSO : 2 mg/mL (7.24 mM; Need ultrasonic)

配制儲備液
濃度溶劑體積質(zhì)量1 mg5 mg10 mg
1 mM3.6194 mL18.0969 mL36.1939 mL
5 mM0.7239 mL3.6194 mL7.2388 mL
10 mM---------
*

請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。



參考文獻

[1]. Kim SY, et al. Effects of Tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytother Res. 2002 Nov;16(7):616-20.  [Content Brief]



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