ATP (腺苷三磷酸)

ATP (Adenosine 5'-triphosphate) 是體內(nèi)能量?jī)?chǔ)存和代謝的重要物質(zhì)，為代謝提供能量，同時(shí)在細(xì)胞中作為輔酶發(fā)揮作用。ATP 是免疫和炎癥中重要的內(nèi)源性信號(hào)分子。

貨號(hào)：HY-B2176
CAS：56-65-5

參數(shù)品牌：MCE

產(chǎn)品參數(shù)

品牌：MCE

型號(hào)：HY-B2176

起訂量：1

規(guī)格:：500mg

價(jià)格:：￥800

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產(chǎn)品詳情

ATP (Adenosine 5'-triphosphate) 是體內(nèi)能量?jī)?chǔ)存和代謝的重要物質(zhì)，為代謝提供能量，同時(shí)在細(xì)胞中作為輔酶發(fā)揮作用。ATP 是免疫和炎癥中重要的內(nèi)源性信號(hào)分子。

生物活性	ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation^[1]^[2].
IC₅₀ & Target	Human Endogenous Metabolite
體外研究 (In Vitro)	ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs^[3]. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner^[4]. ATP promotes neutrophil chemotaxis in vitro
體內(nèi)研究 (In Vivo)	ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo^[4]. ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo^[4]. Animal Model:Four-week-old Kunming mice (18-22 g) Dosage:50 mg/kg Administration:Intraperitoneal injection, before bacterial (E. coli) challenge Result:Protected mice from bacterial infection.
分子量	507.18
運(yùn)輸條件	Room temperature in continental US; may vary elsewhere.
參考文獻(xiàn)	[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.

ATP (腺苷三磷酸)

品牌：MCE

型號(hào)：HY-B2176

起訂量：1

規(guī)格:：500mg

價(jià)格:：￥800

15906629305

在線客服

客服一

產(chǎn)品詳情

生物活性	ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation^[1]^[2].
IC₅₀ & Target	Human Endogenous Metabolite
體外研究 (In Vitro)	ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs^[3]. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner^[4]. ATP promotes neutrophil chemotaxis in vitro
體內(nèi)研究 (In Vivo)	ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo^[4]. ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo^[4]. Animal Model:Four-week-old Kunming mice (18-22 g) Dosage:50 mg/kg Administration:Intraperitoneal injection, before bacterial (E. coli) challenge Result:Protected mice from bacterial infection.
分子量	507.18
運(yùn)輸條件	Room temperature in continental US; may vary elsewhere.
參考文獻(xiàn)	[1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.