SBE-β-CD (Synonyms: 磺丁基-β-環(huán)糊精）

SBE-β-CD 是磺基丁基醚 β-cyclodextrin 衍生物，其用作賦形劑或助溶劑以增加難溶藥物的溶解度。

生物活性

SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents^[1]

體外研究(In Vitro)

SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range^[1].

體內(nèi)研究(In Vivo)

20% SBE-β-CD in saline:
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution.
2. Measure 2 g of dry SBE-β-CD.
3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use.

分子量：2083-2257

CAS 號(hào)：182410-00-0

中文名稱：磺丁基-β-環(huán)糊精；磺丁基醚-β-環(huán)糊精

運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式：4°C, sealed storage, away from moisture and light

溶解性數(shù)據(jù)：H₂O : 125 mg/mL (Need ultrasonic)

參考文獻(xiàn)

[1]. Fukuda M, et al.Influence of sulfobutyl ether beta-cyclodextrin (Captisol) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion.Int J Pharm. 2008 Feb 28;350(1-2):188-196

[2]. Charman SA, et al. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci. 2006 Feb;95(2):256-67