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Melatonin (褪黑素）

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Melatonin 是一種由松果體分泌的ji素，可ji活褪黑ji素受體。Melatonin 在睡眠中起作用并具有重要的抗氧化和抗炎特性。Melatonin 是一種新型的選擇性 ATF-6 抑制劑，可通過 COX-2 下調誘導人肝癌細胞凋亡。Melatonin 通過內質網應激減弱palmitic acid-induced (HY-N0830)誘導的小鼠顆粒細胞凋亡。貨號：HY-B0075 ，CAS：73-31-4
參數(shù)品牌：MCE
產品參數(shù)
品牌：MCE
型號：HY-B0075
起訂量：1
規(guī)格:：1g
價格:：￥500
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產品詳情

Melatonin (Synonyms: 褪黑素; N-Acetyl-5-methoxytryptamine)

Melatonin 是一種由松果體分泌的ji素，可ji活褪黑ji素受體。Melatonin 在睡眠中起作用并具有重要的抗氧化和抗炎特性。Melatonin 是一種新型的選擇性 ATF-6 抑制劑，可通過 COX-2 下調誘導人肝癌細胞凋亡。Melatonin 通過內質網應激減弱palmitic acid-induced (HY-N0830)誘導的小鼠顆粒細胞凋亡。

生物活性

Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].


IC50 & Target

Microbial Metabolite    Human Endogenous Metabolite


體內研究(In Vivo)

Melatonin increases the levels of activated PTEN, RSK-1, mTOR and AMPKα kinases, mildly inhibits ERK-1/2 phosphorylation and Bad phosphorylation, significantly inhibits phosphorylations of S6 Ribosomal Protein, 4E-BP1, GSK-3α and GSK-3β, and slightly increases PRAS40 phosphorylation in animals[1]. Melatonin ameliorates the neurotoxiciy and astrocyte activation induced by Aβ1-42 in the cerebral cortex. Melatonin also blocks the reduction in Reelin and Dab1 expression induced by Aβ1-42[2]. Melatonin treatment and lack of NLRP3-/- share similar inhibition of NF-κB and NLRP3 signaling pathway in mice. Melatonin treatment and lack of NLRP3-/- share some patterns of clock genes expression, and improve cardiomyocytes morphology in mice[3].


分子量：232.28


Formula：C13H16N2O2


CAS 號：73-31-4


中文名稱：褪黑素；褪黑激素；美拉酮寧；抑黑素；松果腺素；松果體素


運輸條件：Room temperature in continental US; may vary elsewhere.


儲存方式

Powder-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month


溶解性數(shù)據


In Vitro: 

DMSO : 100 mg/mL (430.51 mM; Need ultrasonic)

Ethanol : 12.5 mg/mL (53.81 mM; Need ultrasonic)

H2O : 1.1 mg/mL (4.74 mM; Need ultrasonic)

配制儲備液
濃度溶劑體積質量1 mg5 mg10 mg
1 mM4.3051 mL21.5257 mL43.0515 mL
5 mM0.8610 mL4.3051 mL8.6103 mL
10 mM0.4305 mL2.1526 mL4.3051 mL
*

請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內使用，-20°C 儲存時，請在 1 個月內使用。

In Vivo:

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實驗結果的可靠性，澄清的儲備液可以根據儲存條件，適當保存；體內實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 1.


    請依序添加每種溶劑： 5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.62 mg/mL (11.28 mM); Clear solution


  • 2.


    請依序添加每種溶劑： 5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.62 mg/mL (11.28 mM); Clear solution


  • 3.


    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution


  • 4.


    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution


  • 5.


    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution


  • 6.


    請依序添加每種溶劑： 10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution


  • 7.


    請依序添加每種溶劑： 10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution


  • 8.


    請依序添加每種溶劑： 10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution




參考文獻

[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665

[2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1

[3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31

[4]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.

[5]. Zhi Chen, et al. Melatonin attenuates palmitic acid-induced mouse granulosa cells apoptosis via endoplasmic reticulum stress. J Ovarian Res. 2019 May 10;12(1):43


Melatonin (褪黑素）

Melatonin (褪黑素）

分享到微信

×
Melatonin 是一種由松果體分泌的ji素，可ji活褪黑ji素受體。Melatonin 在睡眠中起作用并具有重要的抗氧化和抗炎特性。Melatonin 是一種新型的選擇性 ATF-6 抑制劑，可通過 COX-2 下調誘導人肝癌細胞凋亡。Melatonin 通過內質網應激減弱palmitic acid-induced (HY-N0830)誘導的小鼠顆粒細胞凋亡。貨號：HY-B0075 ，CAS：73-31-4
品牌：MCE
型號：HY-B0075
起訂量：1
規(guī)格:：1g
價格:：￥500
15906629305
在線客服
產品詳情

Melatonin (Synonyms: 褪黑素; N-Acetyl-5-methoxytryptamine)

Melatonin 是一種由松果體分泌的ji素，可ji活褪黑ji素受體。Melatonin 在睡眠中起作用并具有重要的抗氧化和抗炎特性。Melatonin 是一種新型的選擇性 ATF-6 抑制劑，可通過 COX-2 下調誘導人肝癌細胞凋亡。Melatonin 通過內質網應激減弱palmitic acid-induced (HY-N0830)誘導的小鼠顆粒細胞凋亡。

生物活性

Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].


IC50 & Target

Microbial Metabolite    Human Endogenous Metabolite


體內研究(In Vivo)

Melatonin increases the levels of activated PTEN, RSK-1, mTOR and AMPKα kinases, mildly inhibits ERK-1/2 phosphorylation and Bad phosphorylation, significantly inhibits phosphorylations of S6 Ribosomal Protein, 4E-BP1, GSK-3α and GSK-3β, and slightly increases PRAS40 phosphorylation in animals[1]. Melatonin ameliorates the neurotoxiciy and astrocyte activation induced by Aβ1-42 in the cerebral cortex. Melatonin also blocks the reduction in Reelin and Dab1 expression induced by Aβ1-42[2]. Melatonin treatment and lack of NLRP3-/- share similar inhibition of NF-κB and NLRP3 signaling pathway in mice. Melatonin treatment and lack of NLRP3-/- share some patterns of clock genes expression, and improve cardiomyocytes morphology in mice[3].


分子量：232.28


Formula：C13H16N2O2


CAS 號：73-31-4


中文名稱：褪黑素；褪黑激素；美拉酮寧；抑黑素；松果腺素；松果體素


運輸條件：Room temperature in continental US; may vary elsewhere.


儲存方式

Powder-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month


溶解性數(shù)據


In Vitro: 

DMSO : 100 mg/mL (430.51 mM; Need ultrasonic)

Ethanol : 12.5 mg/mL (53.81 mM; Need ultrasonic)

H2O : 1.1 mg/mL (4.74 mM; Need ultrasonic)

配制儲備液
濃度溶劑體積質量1 mg5 mg10 mg
1 mM4.3051 mL21.5257 mL43.0515 mL
5 mM0.8610 mL4.3051 mL8.6103 mL
10 mM0.4305 mL2.1526 mL4.3051 mL
*

請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內使用，-20°C 儲存時，請在 1 個月內使用。

In Vivo:

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實驗結果的可靠性，澄清的儲備液可以根據儲存條件，適當保存；體內實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 1.


    請依序添加每種溶劑： 5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.62 mg/mL (11.28 mM); Clear solution


  • 2.


    請依序添加每種溶劑： 5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.62 mg/mL (11.28 mM); Clear solution


  • 3.


    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution


  • 4.


    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution


  • 5.


    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution


  • 6.


    請依序添加每種溶劑： 10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution


  • 7.


    請依序添加每種溶劑： 10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution


  • 8.


    請依序添加每種溶劑： 10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.76 mM); Clear solution




參考文獻

[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665

[2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1

[3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31

[4]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.

[5]. Zhi Chen, et al. Melatonin attenuates palmitic acid-induced mouse granulosa cells apoptosis via endoplasmic reticulum stress. J Ovarian Res. 2019 May 10;12(1):43


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