Chloroquine (氯喹)

Chloroquine 是一種廣用于瘧疾和類風(fēng)濕性關(guān)節(jié)炎的抗yan試劑。Chloroquine 是自噬 (autophagy) 和 Toll 樣受體 (TLRs) 的抑制劑。貨號(hào)：HY-17589A

參數(shù)品牌：MCE

產(chǎn)品參數(shù)

品牌：MCE

型號(hào)：HY-17589A

起訂量：1

規(guī)格:：100mg

價(jià)格:：￥500

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Chloroquine (Synonyms: 氯喹)

生物活性	Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC₅₀=1.13 μM)^[1]^[2]^[3]^[4].
IC₅₀ & Target^[1]^[2][3]^[5]	HIV-1 Malaria TLRs SARS-COV-2
體外研究 (In Vitro)	Chloroquine (CHQ, 20 μM) inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells (MoLC). Chloroquine (20 μM) enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4⁺ T cells^[1]. Chloroquine (25 μM) suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. Chloroquine has cell-, dose- and hypoxia-dependent effects on MMP-2, MMP-9 and MMP-13 mRNA expression^[2]. TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly reduces HuH7 cell proliferation in vitro^[3]. Chloroquine (0.01-100 μM; 48?hours) potently blocked virus infection (vero E6 cells infected with SARS-CoV-2) at low-micromolar concentration (EC₅₀=1.13?μM). Chloroquine blocks virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV^[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究 (In Vivo)	Chloroquine (80 mg/kg, i.p.) does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model^[2]. TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly inhibits tumour growth in the mouse xenograft model. HCC development in the DEN/NMOR rat model is also significantly inhibited by Chloroquine^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	319.87
Formula	C₁₈H₂₆ClN₃
CAS 號(hào)	54-05-7
中文名稱	氯喹
運(yùn)輸條件	Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
參考文獻(xiàn)	[1]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43. [2]. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672. [3]. Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626. [4]. Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55(4):105932. [5]. Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001;20(3):131-135.