Doxorubicin hydrochloride (鹽酸阿霉素)

Doxorubicin (Hydroxydaunorubicin) hydrochloride是一種具有細胞毒性的蒽環(huán)類抗生素，是一種抗癌化療試劑。Doxorubicin hydrochloride 是一種有效的人類 DNA topoisomerase I 和 topoisomerase II 抑制劑，IC50 分別為 0.8 μM 和 2.67 μM。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰輔酶 A 羧化酶的磷酸化。還可誘導凋亡 (apoptosis) 和自噬。
貨號：HY-15142

參數(shù)品牌：MCE

產(chǎn)品參數(shù)

品牌：MCE

型號：HY-15142

起訂量：1

規(guī)格:：50mg

價格:：￥900

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Doxorubicin hydrochloride (Synonyms: 鹽酸阿霉素; Hydroxydaunorubicin hydrochloride)

生物活性	Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy^[1]^[2]^[3].
IC₅₀ & Target^[1]^[2]^[3]	Topoisomerase II	Daunorubicins/Doxorubicins	Topoisomerase I	HIV-1
	2.67 μM (IC₅₀)		0.8 μM (IC₅₀)
體外研究 (In Vitro)	Doxorubicin hydrochloride (1-8 μM; 24 and 48 hours) decreases the viability of MCF-10F, MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner^[4]. Doxorubicin hydrochloride (1 μM; 3 and 24 hours) results in Hct-116 human colon carcinoma cells reduction in G0/G1 phase and accumulation in G2 phase^[5]. Doxorubicin hydrochloride (1 μM for MCF-10F and MDA-MB-231 cells, 4 μM for MCF-7 cells; 48 hours) induces apoptosis by upregulating Bax, caspase-8 and caspase-3 and downregulation of Bcl-2 protein expression^[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay^[4]
	Cell Line:	Breast cancer cell lines MCF-10F, MCF-7 and MDA-MB-231
	Concentration:	0, 1, 2, 4 and 8 μM
	Incubation Time:	24 and 48 hours
	Result:	IC₅₀ was 1 μM for both MCF-10F and MDA-MB-231 cell lines. IC₅₀ was 4 μM for MCF-7 cell line.
體內(nèi)研究 (In Vivo)	Treatment with Doxorubicin (2 mg/kg) or Zoledronic acid (100 μg/kg) alone does not statistically significantly decrease final tumor volume compared with saline. Mice treated with Doxorubicin plus Zoledronic acid have statistically significantly smaller final tumor volumes than those treated with Doxorubicin alone^[6]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
	Animal Model:	Female MF1 nu/nu mice bearing MDA-G8 breast tumor xenograft (6-week-old)^[6]
	Dosage:	Doxorubicin (2 mg/kg); Zoledronic acid (100 μg/kg)
	Administration:	Intravenous injection; once a week; 6 weeks
	Result:	Moderate inhibition of subcutaneous tumor growth in mice that were treated with 2 mg/kg Doxorubicin alone or with 100 μg/kg Zoledronic acid alone compared to the saline control. Mice treated with Zoledronic acid and Doxorubicin together had statistically significant smaller mean tumor volumes on day 42 than those treated with Doxorubicin alone.
分子量	579.98
Formula	C₂₇H₃₀ClNO₁₁
CAS 號	25316-40-9
中文名稱	鹽酸阿霉素；鹽酸多柔比星
運輸條件	Room temperature in continental US; may vary elsewhere.
儲存方式	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
參考文獻	[1]. John L. Nitiss, et al. Targeting DNA topoisomerase II in cancer chemotherapy.Nat Rev Cancer. 2009 May;9(5):338-50. [2]. Hee-KyungRhee,et al. Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones. Bioorg Med Chem. 2007 Feb 15;15(4):1651-8. [3]. P D Foglesong, et al. Doxorubicin inhibits human DNA topoisomerase I. Cancer Chemother Pharmacol. 1992;30(2):123-5. [4]. Nesstor Pilco-Ferreto, et al. Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines. Int J Oncol. 2016 Aug;49(2):753-62. [5]. Regine Lüpertz, et al. Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells. Toxicology. 2010 May 27;271(3):115-21. [6]. Penelope D Ottewell, et al. Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer. J Natl Cancer Inst. 2008 Aug 20;100(16):1167-78.

說明書：https://file.medchemexpress.cn/batch_PDF/HY-15142/Doxorubicin-hydrochloride-DataSheet-MedChemExpress.pdf